| Depakote
(Divalproex) is an anticonvulsant used to control seizures. It may
also be used to treat migraine headaches manic episodes and other
conditions as determined by your doctor.
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About Depakote (Divalproex):
Product Type: Migraines
Brand name: Depakote Generic
name: Divalproex What is the most important information I should
know about Depakote? • In rare cases Depakote has caused life-threatening
liver failure especially in children younger than 2 years old. Children
of this age may be at even greater risk for liver problems if they
use more than one seizure medication if they have a metabolic disorder
or if they have a brain disease causing mental impairment (such
as Creutzfeldt-Jacob disease Huntington disease multiple sclerosis
or a brain injury or infection). • Depakote has also caused rare
cases of life-threatening pancreatitis (inflammation of the pancreas).
Pancreatitis can come on suddenly and symptoms may start even after
you have been taking Depakote for several years. • Seek emergency
medical attention if the person taking this medicine has nausea
vomiting stomach pain or loss of appetite low fever dark urine clay-colored
stools or jaundice (yellowing of the skin or eyes). These symptoms
may be early signs of liver damage. Some of these symptoms may also
be early signs of pancreatitis. • Do not use this medication without
your doctor's consent if you are pregnant. It could cause harm to
the unborn baby. Use an effective form of birth control and tell
your doctor if you become pregnant during treatment. • Do not stop
taking the medication even if you feel better. It is important to
take Depakote regularly to prevent seizures from recurring. Call
your doctor promptly if this medicine does not seem to be working
as well in preventing your seizures. • Do not crush chew break or
open a delayed-release or extended-release tablet or capsule. Swallow
the pill whole. It is specially made to release medicine slowly
in the body. Breaking or opening the pill would cause too much of
the drug to be released at one time. • Carry an ID card or wear
a medical alert bracelet stating that you are taking Depakote in
case of emergency. Any doctor dentist or emergency medical care
provider who treats you should know that you are taking Depakote.
• Avoid using other drugs that make you sleepy (such as other seizure
medicines alcohol cold medicine pain medication muscle relaxers
and medicine for depression or anxiety). They can add to sleepiness
caused by Depakote. What is Depakote? • Depakote affects chemicals
in the body that may be involved in causing seizures. • Depakote
is used to treat various types of seizure disorders. Depakote is
sometimes used together with other seizure medications. • Depakote
may also be used for purposes other than those listed in this medication
guide. What should I discuss with my healthcare provider before
taking Depakote? • In rare cases Depakote has caused life-threatening
liver failure especially in children younger than 2 years old. Children
of this age may be at even greater risk for liver problems if they
use more than one seizure medication if they have a metabolic disorder
or if they have a brain disease causing mental impairment (such
as Creutzfeldt-Jacob disease Huntington disease multiple sclerosis
or a brain injury or infection). • Depakote has also caused rare
cases of life-threatening pancreatitis (inflammation of the pancreas).
Pancreatitis can come on suddenly and symptoms may start even after
you have been taking Depakote for several years. • Do not take Depakote
if you have liver disease or a urea cycle disorder. • Before taking
Depakote tell your doctor if you have: a bleeding or blood clotting
disorder; a history of head injury brain disorder or coma; a family
history of a urea cycle disorder; a family history of infant deaths
with unknown cause; or HIV or CMV (cytomegalovirus) infection. •
If you have any of these conditions you may not be able to use Depakote
or you may need a dosage adjustment or special tests during treatment.
• FDA pregnancy category D. This medication can cause harm to an
unborn baby. Do not use Depakote without your doctor's consent if
you are pregnant. Tell your doctor if you become pregnant during
treatment. Use an effective form of birth control while you are
using this medication. • Depakote passes into breast milk and could
harm a nursing infant. Do not take Depakote without telling your
doctor if you are breast-feeding a baby. • Depakote should not be
given to a child younger than 2 years of age without a doctor's
consent. • Older adults may be more sensitive to sleepiness caused
by this medicine. How should I take Depakote? • Take this medication
exactly as it was prescribed for you. Do not take the medication
in larger amounts or take it for longer than recommended by your
doctor. • Take each dose with a full glass of water. Drink plenty
of water while you are taking this medication. Your dose may need
to be changed if you do not get enough fluids each day. • To be
sure this medication is not causing harmful effects your liver function
will need to be tested. It is important that you not miss any scheduled
visits to your doctor. • Do not stop taking the medication even
if you feel better. It is important to take Depakote regularly to
prevent seizures from recurring. Get your prescription refilled
before you run out of medicine completely. Call your doctor promptly
if this medicine does not seem to be working as well in preventing
your seizures. • Do not crush chew break or open a delayed-release
or extended-release tablet or capsule. Swallow the pill whole. It
is specially made to release medicine slowly in the body. Breaking
or opening the pill would cause too much of the drug to be released
at one time. • Carry an ID card or wear a medical alert bracelet
stating that you are taking Depakote in case of emergency. Any doctor
dentist or emergency medical care provider who treats you should
know that you are taking Depakote. • Store Depakote at room temperature
away from moisture and heat. What happens if I miss a dose? • Take
the missed dose as soon as you remember. If it is almost time for
your next dose skip the missed dose and take the medicine at the
next regularly scheduled time. Do not take extra medicine to make
up the missed dose. What happens if I overdose? • Seek emergency
medical attention if you think you have used too much of this medicine.
• Symptoms of a Depakote overdose may include sleepiness or drowsiness
shallow breathing weak pulse or loss of consciousness. What should
I avoid while taking Depakote? • Avoid drinking alcohol which can
increase some of the side effects of Depakote. • Avoid using other
medicines that make you sleepy (such as cold medicine pain medication
muscle relaxers and medicine for seizures depression or anxiety).
They can add to sleepiness caused by Depakote. • Depakote can cause
side effects that may impair your thinking or reactions. Be careful
if you drive or do anything that requires you to be awake and alert.
• Avoid exposure to sunlight or artificial UV rays (sunlamps or
tanning beds). Depakote can make your skin more sensitive to sunlight
and sunburn may result. Use a sunscreen (minimum SPF 15) and wear
protective clothing if you must be out in the sun. What are the
possible side effects of Depakote? • Seek emergency medical attention
if the person taking this medicine has nausea vomiting stomach pain
or loss of appetite low fever dark urine clay-colored stools or
jaundice (yellowing of the skin or eyes). These symptoms may be
early signs of liver damage. Some of these symptoms may also be
early signs of pancreatitis. • Get emergency medical help if you
have any of these signs of an allergic reaction: hives; difficulty
breathing; swelling of your face lips tongue or throat. • Call your
doctor at once if you have any of these serious side effects: unexplained
weakness with vomiting and confusion or fainting; easy bruising
or bleeding unusual weakness; fever skin rash swollen glands; fever
chills body aches flu symptoms; urinating less than usual; blood
in your urine; hallucinations (seeing things that aren't there);
weakness lack of coordination; a red blistering peeling skin rash;
extreme drowsiness; unusual bleeding or bruising; or double vision
or back-and-forth movements of the eyes. • Continue using Depakote
and talk with your doctor if you have any of these less serious
side effects: drowsiness or weakness; diarrhea constipation upset
stomach; depression anxiety or other emotional changes; changes
in your menstrual periods; enlarged breasts; tremor (shaking); hair
loss; weight changes; a red blistering peeling skin rash; vision
changes; or unusual or unpleasant taste in your mouth. • Side effects
other than those listed here may also occur. Talk to your doctor
about any side effect that seems unusual or that is especially bothersome.
What other drugs will affect Depakote? • Before taking Depakote
tell your doctor if you are using any of the following drugs: topiramate
(Topamax); tolbutamide (Orinase); a blood thinner such as warfarin
(Coumadin); aspirin or acetaminophen (Tylenol); zidovudine (Retrovir);
clozapine (Clozaril Fazaclo); diazepam (Valium); meropenem (Merrem);
rifampin (Rifadin Rimactane Rifater); ethosuximide (Zarontin); or
another seizure medicine such as phenytoin (Dilantin) carbamazepine
(Tegretol Carbatrol) phenobarbital (Luminal Solfoton) felbamate
(Felbatol) lamotrigine (Lamictal) or clonazepam (Klonopin). • If
you are using any of these drugs you may not be able to use Depakote
or you may need dosage adjustments or special tests during treatment.
• There may be other drugs not listed that can affect Depakote.
Tell your doctor about all the prescription and over-the-counter
medications you use. This includes vitamins minerals herbal products
and drugs prescribed by other doctors. Do not start using a new
medication without telling your doctor.
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Medication News : ASNC: More Patients May Be Candidates for Exercise Stress (CME/CE). DENVER -- Primary care physicians appear more likely to select patients for pharmacological stress testing, even though these patients may be capable of an exercise stress test, a single-center study found. Of 120 patients referred for pharmacological stress testing, 60% were able to reach the target heart rate of 85% maximum predicted heart rate (MPR) with exercise alone, Michael Ross, MD, and colleagues from Northwestern University in Chicago, reported here at the American Society of Nuclear Cardiology meeting. Of those who reached 85% of MPR (72) by exercise only, 43% were referred by surgeons, 24% by cardiologists, and 33% by primary care physicians, of which the latter reached significance (P=0.02). Most surgical referrals for pharmacological stress tests are for preoperative evaluation, and many of these are for liver and kidney transplants, Ross told MedPage Today.
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